SCHEMBL7404104

SCHEMBL7404104

Cc1ccc(C(O)c2ccncc2)c(F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 1/20 0.40
CRHR1 P34998 1/20 0.39
CYP17A1 P05093 2/20 0.39
CYP3A4 P08684 1/20 0.39
CYP19A1 P11511 1/20 0.39
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
BRD4 O60885 2/20 0.35
CYP46A1 Q9Y6A2 1/20 0.35
LMNA P02545 2/20 0.34
TRPA1 O75762 1/20 0.34
CHRM1 P11229 1/20 0.34
SLC6A2 P23975 1/20 0.34
ADRA1A P35348 1/20 0.34
HTR2B P41595 1/20 0.34
DPP4 P27487 1/20 0.34
GAA P10253 1/20 0.34
RPS6KA3 P51812 1/20 0.34
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14676330 0.83 MLKL (0.45) BRD4LMNATRPA1CHRM1SLC6A2
SCHEMBL10112238 0.80 CYP17A1 (0.39) PDE4BCYP17A1CYP3A4CYP19A1CYP11B1
SCHEMBL20158076 0.80 POLB (0.40) PDE4BCRHR1CYP17A1CYP3A4CYP19A1
SCHEMBL22417078 0.78 ACHE (0.39) BRD4LMNATRPA1CHRM1SLC6A2
SCHEMBL23882758 0.75 HDAC4 (0.47) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL23882759 0.75 HDAC4 (0.47) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL8737044 0.74 CYP19A1 (0.59) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL18862637 0.74 TRPA1 (0.43) LMNATRPA1CHRM1SLC6A2ADRA1A
SCHEMBL1631081 0.72 CES2 (0.44) PDE4BCYP17A1CYP3A4CYP19A1CYP11B1
SCHEMBL13345087 0.72 TRPA1 (0.47) LMNATRPA1CHRM1SLC6A2ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6124323-A ACTIVE DRUG TREATING STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMIOGLYCOSIDE ANTIBIOTICS-INDUCED HEARING LOSS, MIGRAINE HEADACHES, CHRONIC PAIN, GLAUCOMA, CMV RETINITIS, PSYCHOSIS WARNER-LAMBERT COMPANY (US) 2000-09-26 US disclosed
EP-0869792-A4 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 1999-09-22 EP disclosed
EP-0869792-A2 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-10-14 EP disclosed
WO-1997023216-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed