Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11784411 | 0.87 | NOS2 (0.35) | GPR84FFAR1DDAH1RNPEPCA1 | |
| SCHEMBL9000037 | 0.85 | CA1 (0.36) | DDAH1RNPEPCA1CA2 | |
| SCHEMBL11150583 | 0.82 | — | — | |
| SCHEMBL28361464 | 0.81 | DDAH1 (0.35) | DDAH1RNPEPCA1CA2 | |
| SCHEMBL7227218 | 0.79 | CA1 (0.48) | GPR84FFAR1CA1CA2 | |
| SCHEMBL29129654 | 0.79 | DDAH1 (0.34) | DDAH1RNPEPCA1CA2 | |
| SCHEMBL11787604 | 0.78 | SMN1; SMN2 (0.33) | GPR84FFAR1FFAR4 | |
| SCHEMBL16013146 | 0.78 | — | — | |
| SCHEMBL10558077 | 0.78 | TBXAS1 (0.43) | GPR84FFAR1FFAR4DDAH1RNPEP | |
| SCHEMBL8417876 | 0.77 | GPR84 (0.47) | GPR84FFAR1FFAR4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885215-A1 | NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997030045-A1 | NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1997-08-21 | — | — | WO | disclosed |