Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404248 | 0.81 | EDNRB (0.61) | EDNRBNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4673253 | 0.75 | ALDH1A1 (0.36) | NPC1LMNAHTTRAB9ASMN1; SMN2 | |
| SCHEMBL10603224 | 0.74 | USP2 (0.54) | NPC1HTTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10606501 | 0.73 | PLAU (0.56) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL10619726 | 0.71 | ALDH1A1 (0.40) | NPC1LMNAHTTRAB9ASMN1; SMN2 | |
| SCHEMBL7401360 | 0.70 | ALDH1A1 (0.60) | EDNRBNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL345281 | 0.68 | CA1 (0.55) | NPC1LMNARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6059109 | 0.67 | CYP3A4 (0.35) | NPC1LMNAHTTRAB9ASMN1; SMN2 | |
| SCHEMBL7399206 | 0.67 | ALDH1A1 (0.66) | EDNRBNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9179233 | 0.66 | PDE4B (0.58) | NPC1HTTRAB9AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650484-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-03 | — | — | EP | claimed |
| WO-1994002474-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-02-03 | — | — | WO | claimed |