Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.47 |
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936012 | 0.85 | NFKB1 (0.45) | PDE4BPDE4APDE4CPDE4DRIPK1 | |
| SCHEMBL4516687 | 0.85 | MAOB (0.55) | PDE4BPDE4APDE4CPDE4DCA12 | |
| SCHEMBL4520573 | 0.84 | MAOB (0.49) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4946009 | 0.83 | MAOB (0.50) | CA9L3MBTL1SMN1; SMN2 | |
| SCHEMBL9078297 | 0.81 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DCA12 | |
| SCHEMBL17212054 | 0.80 | MAPT (0.51) | SMN1; SMN2POLB | |
| SCHEMBL7451474 | 0.80 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DCA12 | |
| SCHEMBL7451477 | 0.80 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DCA12 | |
| SCHEMBL598460 | 0.80 | CA9 (0.68) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20207066 | 0.78 | RIPK1 (0.40) | PDE4BPDE4APDE4CPDE4DRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097921-A1 | Phenylhydrazines | SANOFI-SYNTHELABO (FR) | 2001-05-09 | — | — | EP | disclosed |
| US-6172239-B1 | PSYCHOLOGICAL, NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 2001-01-09 | — | — | US | disclosed |
| US-5965579-A | ANTAGONISTS OF THE NEUROTENSIN RECEPTORS; INCREASING AFFINITY FOR HUMAN NEUROTENSIN RECEPTORS | SANOFI (FR) | 1999-10-12 | — | — | US | disclosed |
| US-5939449-A | NOVEL COMPOUNDS HAVING HIGH AFFINITY FOR THE NEUROTENSIN RECEPTORS | SANOFI (FR) | 1999-08-17 | — | — | US | disclosed |
| US-5936123-A | COMPOUNDS SUCH AS 3-ISOPROPYL-4-HYDRAZINOBENZOIC ACID AND ITS SALTS | SANOFI (FR) | 1999-08-10 | — | — | US | disclosed |
| US-5925661-A | NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 1999-07-20 | — | — | US | disclosed |
| US-5723483-A | NEUROTENSIN ANTAGONIST, HYPOTENSIVE AGENTS AND FOR NEUROPSYCHIATRIC DISORDERS | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| WO-1996032382-A1 | 1-PHENYLPYRAZOLE-3-CARBOXAMIDES ACTING ON NEUROTENSIN RECEPTORS | SANOFI (FR) | 1996-10-17 | — | — | WO | disclosed |
| US-5561234-A | EXHIBIT HIGH AFFINITY FOR THE NEUROTENSIN RECEPTOR | SANOFI (FR) | 1996-10-01 | — | — | US | disclosed |
| EP-0695747-A1 | Derivatives of substituted N-oxide 1-(7-chloroquinolin-4-yl)pyrozole-3-carboxamides as ligand of the neurotensin receptor | SANOFI (FR) | 1996-02-07 | — | — | EP | disclosed |