Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.56 |
| ▸ | NPC1 | O15118 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340325 | 0.81 | GRM5 (0.56) | RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL7334320 | 0.81 | KDM4E (0.52) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7406442 | 0.79 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7336457 | 0.78 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7337895 | 0.78 | DNM1 (0.38) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL7346861 | 0.77 | SIRT2 (0.53) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7341819 | 0.77 | SIRT2 (0.54) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL7334154 | 0.76 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL7343154 | 0.76 | MAPT (0.60) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7345841 | 0.75 | ALDH1A1 (0.53) | RAB9ANPC1SMN1; SMN2TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | STEELE ANDREW W (US) | 2001-12-06 | — | — | US | disclosed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | SERPINE1, PLAU, SERPINB1 | RAB9A 2845/4885NPC1 2478/4885SMN1; SMN2 1786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.