SCHEMBL7407170

SCHEMBL7407170

CC(=O)CCC(Cl)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
MTNR1A P48039 1/20 0.44
MTNR1B P49286 1/20 0.44
HPGD P15428 1/20 0.43
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C19 P33261 1/20 0.39
CYP2D6 P10635 1/20 0.39
SRC P12931 1/20 0.39
TSHR P16473 1/20 0.38
ALOX5 P09917 1/20 0.38
LMNA P02545 2/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8166351 0.84 CYP2D6 (0.41) ALDH1A1MTNR1AMTNR1BHPGDCYP2C19
SCHEMBL7910713 0.84 CYP2D6 (0.48) ALDH1A1HPGDKDM4ECYP2C19CYP2D6
SCHEMBL1132531 0.84 CYP2D6 (0.48) ALDH1A1HPGDKDM4ECYP2C19CYP2D6
SCHEMBL11543107 0.82 MTNR1A (0.58) ALDH1A1MTNR1AMTNR1B
SCHEMBL6404252 0.81 CYP2D6 (0.46) CYP2C19CYP2D6SRCALOX5LMNA
SCHEMBL4729080 0.80 ALDH1A1 (0.50) ALDH1A1MTNR1AMTNR1BHPGDKDM4E
SCHEMBL3825678 0.80 KDM4E (0.50) ALDH1A1MTNR1AMTNR1BHPGDKDM4E
SCHEMBL3832812 0.80 CTSA (0.39) ALDH1A1HPGDCYP2D6
SCHEMBL27913389 0.79 L3MBTL1 (0.52) ALDH1A1HPGDKDM4EMAPTCYP2C19
SCHEMBL28304435 0.79 HDAC3 (0.46) ALDH1A1MTNR1AMTNR1BCYP2C19CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1315780-C Process for producing n-(1-(2,4-dichlorophenyl)ethyl)-2- cyano-3,3-dimethylbutanamide SUMITOMO CHEMICAL CO (JP) 2007-05-16 CN disclosed
CN-1243719-C Process for producing N- [1- (2, 4-dichlorophenyl) ethyl ] -2-cyano-3, 3-dimethylbutanamide SUMITOMO CHEMICAL CO (JP) 2006-03-01 CN disclosed
CN-1243720-C Process for producing n-(1-(2,4-dichlorophenyl)ethyl)-2- cyano-3,3-dimethylbutanamide SUMITOMO CHEMICAL CO (JP) 2006-03-01 CN disclosed
CN-1680273-A Process for producing n-(1-(2,4-dichlorophenyl)ethyl)-2- cyano-3,3-dimethylbutanamide SUMITOMO CHEMICAL CO (JP) 2005-10-12 CN disclosed
CN-1526696-A Process for producing N- [ 1- (2, 4-dichlorophenyl) ethyl ] -2-cyano-3, 3-dimethylbutanamide 住友化学工业株式会社 2004-09-08 CN disclosed
CN-1524845-A Process for producing n-(1-(2,4-dichlorophenyl)ethyl)-2- cyano-3,3-dimethylbutanamide 住友化学工业株式会社 2004-09-01 CN disclosed
CN-1153762-C Process for producing N- [1- (2, 4-dichlorophenyl) ethyl ] -2-cyano-3, 3-dimethylbutanamide 住友化学工业株式会社 2004-06-16 CN disclosed
US-6087346-A Sigma receptor ligands and the use thereof CAMBRIDGE NEUROSCIENCE, INC. (US) 2000-07-11 US disclosed
EP-0865426-A1 AMINO ACID DERIVATIVES, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHODS OF PRODUCING SAID COMPOUNDS Dr. Karl Thomae GmbH (DE) 1998-09-23 EP disclosed
WO-1997019914-A1 AMINO ACID DERIVATIVES, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHODS OF PRODUCING SAID COMPOUNDS DR. KARL THOMAE GMBH (DE) 1997-06-05 WO disclosed
EP-0714292-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF CAMBRIDGE NEUROSCIENCE INC (US) 1996-10-09 EP disclosed
CN-1131146-A Process for producing N- [1- (2, 4-dichlorophenyl) ethyl ] -2-cyano-3, 3-dimethylbutanamide SUMITOMO CHEMICAL CO (JP) 1996-09-18 CN disclosed
EP-0714292-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF CAMBRIDGE NEUROSCIENCE, INC. (US) 1996-06-05 EP disclosed
WO-1995000131-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) 1995-01-05 WO disclosed