Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 9/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6246115 | 0.95 | DRD2 (0.46) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL7407894 | 0.94 | GPR84 (0.46) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL7411386 | 0.90 | DRD2 (0.49) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL6025264 | 0.85 | DRD2 (0.51) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL1939638 | 0.83 | DRD2 (0.50) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL29460523 | 0.80 | RIPK1 (0.60) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL3492565 | 0.77 | DRD2 (0.58) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL25230913 | 0.76 | DRD2 (0.50) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL13543890 | 0.76 | RIPK1 (0.58) | DRD2DRD4DRD3CCNE1CDK2 | |
| SCHEMBL2176426 | 0.76 | LOXL2 (0.52) | DRD2DRD4DRD3CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1039714-C | Substituted indole, azaindole and tetrahydro-1H-pyrrol pyrrolo [2,3-c] pyridin-7-one derivatives | SYTEX U S A INC (US) | 1998-09-09 | — | — | CN | disclosed |
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| CN-1078469-A | Substituted indole, the assorted indoles of ammonia and tetrahydro-1 H-pyrrolo be [2,3-c] pyridin-7-one derivatives also | SYTEX A INC (US) | 1993-11-17 | — | — | CN | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |