Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449696 | 0.90 | DRD3 (0.47) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL7408451 | 0.89 | DRD2 (0.42) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL7411601 | 0.89 | DRD3 (0.48) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL7457771 | 0.86 | FNTA (0.40) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL8094410 | 0.86 | GRM2 (0.41) | HTR1ADRD3ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL7451624 | 0.84 | FYN (0.45) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL7404669 | 0.76 | FYN (0.51) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL7456278 | 0.74 | DRD3 (0.50) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL8109777 | 0.73 | DRD3 (0.50) | FYNHTR1ADRD3ALDH1A1CYP2D6 | |
| SCHEMBL8103965 | 0.72 | ALDH1A1 (0.55) | FYNHTR1ADRD3ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |