Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414642 | 1.00 | NPC1 (0.55) | NPC1MEN1KMT2ARAB9ATDP1 | |
| SCHEMBL7411350 | 0.88 | GPR27 (0.51) | NPC1MEN1KMT2ASLC16A3F2 | |
| SCHEMBL7411445 | 0.86 | ALDH1A1 (0.54) | NPC1MEN1KMT2ARAB9ANR1H4 | |
| SCHEMBL7411398 | 0.86 | ALDH1A1 (0.54) | NPC1MEN1KMT2ARAB9ANR1H4 | |
| SCHEMBL7460237 | 0.85 | NR1H4 (0.47) | NPC1MEN1KMT2ARAB9ATDP1 | |
| SCHEMBL7413497 | 0.84 | SLC16A3 (0.52) | KMT2ASLC16A3F2PRSS1 | |
| SCHEMBL7409765 | 0.83 | NPC1 (0.46) | NPC1RAB9ATDP1NR1H4KDM4E | |
| SCHEMBL7413259 | 0.83 | MEN1 (0.56) | NPC1MEN1KMT2ARAB9ATDP1 | |
| SCHEMBL7409183 | 0.81 | MEN1 (0.84) | NPC1MEN1KMT2ARAB9AKDM4E | |
| SCHEMBL7410644 | 0.81 | MEN1 (0.84) | NPC1MEN1KMT2ARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999042439-A1 | NOVEL THIOBENZAMIDES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-26 | — | — | WO | claimed |
| WO-1999042439-A1 | NOVEL THIOBENZAMIDES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-26 | — | — | WO | disclosed |
| EP-0937711-A1 | Thiobenzamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-08-25 | — | — | EP | disclosed |