Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114768 | 0.87 | SMN1; SMN2 (0.47) | KMT2ATSHRSMN1; SMN2CASP3SENP8 | |
| SCHEMBL8993708 | 0.82 | ALDH1A1 (0.45) | KMT2ATSHRSMN1; SMN2HSD17B10NPSR1 | |
| SCHEMBL28860543 | 0.81 | HTT (0.61) | KMT2ATSHRSMN1; SMN2NPSR1RXFP1 | |
| SCHEMBL9817222 | 0.80 | CYP2C19 (0.59) | KMT2ATSHRSMN1; SMN2CASP3SENP8 | |
| SCHEMBL2803342 | 0.79 | SLC9A1 (0.55) | KMT2ATSHRSMN1; SMN2GAANPSR1 | |
| SCHEMBL16858648 | 0.79 | GAA (0.50) | KMT2ATSHRSMN1; SMN2GAANPSR1 | |
| SCHEMBL29475407 | 0.79 | GAA (0.50) | KMT2ATSHRSMN1; SMN2GAANPSR1 | |
| SCHEMBL6273531 | 0.78 | TSHR (0.53) | KMT2ATSHRSMN1; SMN2NPSR1RXFP1 | |
| SCHEMBL9767195 | 0.77 | ALDH1A1 (0.41) | KMT2ATSHRSMN1; SMN2NPSR1RXFP1 | |
| SCHEMBL958454 | 0.75 | TSHR (0.50) | KMT2ATSHRSMN1; SMN2GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364848-A | Elastase inhibitors | MERCK & CO., INC. (US) | 1994-11-15 | — | — | US | disclosed |
| US-5132301-A | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0170192-B1 | PENICILLIN DERIVATIVES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO. INC. (US) | 1992-05-13 | — | — | EP | disclosed |
| US-4891370-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4797396-A | INHIBITION OF ELASTASE, ANTIBIOTICS | MERCK & CO., INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0267723-A2 | New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO. INC. (US) | 1988-05-18 | — | — | EP | disclosed |
| US-4717722-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1988-01-05 | — | — | US | disclosed |
| US-4711886-A | β-lactam derivatives as anti-inflammatory and antidegenerative agents | MERCK & CO., INC. (US) | 1987-12-08 | — | — | US | disclosed |
| US-4623645-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1986-11-18 | — | — | US | disclosed |
| US-4547371-A | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO., INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4495197-A | N-Carboxyl-thienamycin esters and analogs thereof as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-01-22 | — | — | US | disclosed |
| US-4493839-A | 1-Carbapenem-3-carboxylic esters as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-01-15 | — | — | US | disclosed |
| US-4465687-A | ANTIARTHRITIC AGENT, ENZYME INHIBITOR | MERCK & CO., INC. (US) | 1984-08-14 | — | — | US | disclosed |