Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PARL | Q9H300 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28569854 | 0.88 | TSHR (0.47) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL9817222 | 0.88 | CYP2C19 (0.59) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL2801877 | 0.88 | SLC9A1 (0.59) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL28479855 | 0.87 | TSHR (0.46) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL11450038 | 0.86 | SLC9A1 (0.44) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL27903206 | 0.84 | KMT2A (0.46) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL11448910 | 0.84 | KMT2A (0.62) | SLC9A1TSHRNPSR1RXFP1KMT2A | |
| SCHEMBL6273531 | 0.83 | TSHR (0.53) | SLC9A1TSHRNPSR1RXFP1CYP2C19 | |
| SCHEMBL3724640 | 0.83 | SMN1; SMN2 (0.47) | SLC9A1TSHRPARLCYP2C19KMT2A | |
| SCHEMBL30695198 | 0.83 | LMNA (0.48) | SLC9A1TSHRNPSR1RXFP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543670-B1 | PYRAZOLOPYRIMIDIN-DERIVATIVE FÜR DIE BEHANDLUNG VON HAUTKRANKHEITEN | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-05-04 | — | — | EP | disclosed |
| CN-102791712-B | Pyrazolopyrimidine Derivatives | KYOWA HAKKO KIRIN CO LTD | 2015-07-01 | — | — | CN | disclosed |
| EP-2206714-B1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| EP-2781216-A1 | CHEMOKINE RECEPTOR ACTIVITY REGULATOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2014-09-24 | — | — | EP | disclosed |
| US-8815874-B2 | Pyrazolopyrimidine derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-20140221340-A1 | CHEMOKINE RECEPTOR ACTIVITY REGULATOR | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-08-07 | — | — | US | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20130102620-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2013-04-25 | — | — | US | disclosed |
| EP-2543670-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| CN-102791712-A | Pyrazolopyrimidine Derivatives | KYOWA HAKKO KIRIN CO LTD | 2012-11-21 | — | — | CN | disclosed |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2206714-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
| US-7635181-B2 | Ink for ink jet-recording curable through irradiation with a radioactive ray and method for preparing lithographic printing plates using the same | FUJIFILM CORPORATION (JP) | 2009-12-22 | — | — | US | disclosed |
| US-7635181-B2 | Ink for ink jet-recording curable through irradiation with a radioactive ray and method for preparing lithographic printing plates using the same | FUJIFILM CORPORATION (JP) | 2009-12-22 | — | — | US | disclosed |
| EP-1589374-B1 | Polymerizable composition and process for producing lithographic plate using the polymerizable composition | FUJIFILM CORP (JP) | 2008-10-01 | — | — | EP | disclosed |
| US-7335466-B2 | Silver salt photothermographic dry imaging material, image recording method and image forming method for the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2008-02-26 | — | — | US | disclosed |
| US-7335466-B2 | Silver salt photothermographic dry imaging material, image recording method and image forming method for the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2008-02-26 | — | — | US | disclosed |
| US-7306894-B2 | Polymerizable composition, photopolymerizing method and process for producing lithographic printing plate using the polymerizable composition | FUJIFILM CORPORATION (JP) | 2007-12-11 | — | — | US | disclosed |
| US-7306894-B2 | Polymerizable composition, photopolymerizing method and process for producing lithographic printing plate using the polymerizable composition | FUJIFILM CORPORATION (JP) | 2007-12-11 | — | — | US | disclosed |
| US-4242507-A | Sulfonic acid esters | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221340-A1 | CHEMOKINE RECEPTOR ACTIVITY REGULATOR | CXCR2, ACKR3, CCR2 | SLC9A1 1742/4885TSHR 440/4885NPSR1 84/4885 |
| US-20130102620-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | GRK3, NR3C2, NR1I3 | SLC9A1 1253/4885TSHR 247/4885NPSR1 1017/4885 |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | TYR, CUTA, SERPINB1 | SLC9A1 118/4885TSHR 4698/4885NPSR1 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.