Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.50 |
| ▸ | REN | P00797 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PEPD | P12955 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337917 | 1.00 | ACE (0.50) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL7058716 | 1.00 | ACE (0.50) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL4902901 | 0.87 | RAB9A (0.56) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL9728258 | 0.82 | ACE (0.53) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL5134719 | 0.78 | ACE (0.57) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL3600173 | 0.78 | ACE (0.57) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL2422749 | 0.77 | ACE (0.48) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL2422744 | 0.77 | ACE (0.48) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL17285637 | 0.76 | ACE (0.51) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL9046806 | 0.75 | NPSR1 (0.55) | ACERENLMNAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395758-B1 | VISION DEFECTS | GPI NIL HOLDINGS, INC. | 2002-05-28 | — | — | US | disclosed |
| US-20020049199-A1 | N-linked carbamates and ureas of heterocyclic thioesters | GLIAMED, INC. | 2002-04-25 | — | — | US | disclosed |
| EP-0959882-A4 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | HAMILTON GREGORY S (US) | 2001-12-05 | — | — | EP | disclosed |
| US-6274607-B1 | INHIBITORS OF PEPTIDYL-PROLYL ISOMERASE, OR ROTAMASE ENZYME ACTIVITY; DO NOT EXERT ANY IMMUNOSUPPRESSIVE ACTIVITY IN ADDITION TO THEIR NEUROTROPHIC ACTIVITY; BIOAVAILABILITY; POTENCY | GPI NIL HOLDINGS, INC. | 2001-08-14 | — | — | US | disclosed |
| EP-1083875-A1 | SMALL MOLECULE CARBAMATE OR UREA HAIR GROWTH COMPOSITIONS AND USES | GPI NIL Holdings, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062484-A1 | SMALL MOLECULE CARBAMATE OR UREA HAIR GROWTH COMPOSITIONS AND USES | GPI NIL HOLDINGS, INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| EP-0959882-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998029117-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049199-A1 | N-linked carbamates and ureas of heterocyclic thioesters | FKBP8, FKBP1A, FKBP3 | ACE 1035/4885REN 1130/4885LMNA 4796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.