Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412479 | 0.78 | PNMT (0.47) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL27185972 | 0.72 | ALDH1A1 (0.55) | KDM4EALDH1A1USP2KDM4CMAPT | |
| SCHEMBL14661038 | 0.70 | HTT (0.39) | KDM4EALDH1A1MAPTLMNAHTT | |
| SCHEMBL2550589 | 0.70 | ACHE (0.45) | KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL4605690 | 0.69 | ALDH1A1 (0.40) | KDM4EALDH1A1USP2GAATSHR | |
| SCHEMBL7033282 | 0.66 | QDPR (0.56) | KDM4EMAPTGAACCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL7030177 | 0.66 | QDPR (0.56) | KDM4EMAPTGAACCNT1CDK9 | |
| SCHEMBL30839803 | 0.66 | MAPT (0.52) | KDM4EALDH1A1USP2KDM4CMAPT | |
| SCHEMBL3784958 | 0.66 | NTRK1 (0.49) | KDM4EALDH1A1USP2KDM4CMAPT | |
| SCHEMBL27185970 | 0.66 | MAPT (0.52) | KDM4EALDH1A1USP2KDM4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027081-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-25 | — | — | WO | disclosed |