Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271695 | 0.90 | HMOX1 (0.41) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7314797 | 0.87 | MAPT (0.41) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7318117 | 0.85 | MAPT (0.41) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7357006 | 0.84 | MAPT (0.40) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7369995 | 0.77 | CTSK (0.40) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9642305 | 0.77 | METAP2 (0.41) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7324654 | 0.77 | METAP2 (0.41) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7321491 | 0.77 | PPARA (0.43) | KMT2A | |
| SCHEMBL10522492 | 0.76 | KLK5 (0.46) | — | |
| SCHEMBL10434937 | 0.76 | TSHR (0.44) | MAPTLMNAKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733882-A | Retroviral protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0602069-A4 | RETROVIRAL PROTEASE INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0602069-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-06-22 | — | — | EP | disclosed |
| WO-1993002057-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-04 | — | — | WO | disclosed |