Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321491 | 0.89 | PPARA (0.43) | CTSKCTSLCTSSREN | |
| SCHEMBL7369996 | 0.86 | CTSK (0.41) | CTSKCTSLCTSSPSMB1 | |
| SCHEMBL10522492 | 0.80 | KLK5 (0.46) | CTSKCTSLCTSS | |
| SCHEMBL7408571 | 0.77 | MAPT (0.45) | LMNAMAPTTDP1CYP1A2CYP2D6 | |
| SCHEMBL7314797 | 0.77 | MAPT (0.41) | CTSKCTSLCTSSLMNAMAPT | |
| SCHEMBL7362345 | 0.75 | FPR2 (0.48) | CTSSLMNAMAPT | |
| SCHEMBL8876703 | 0.75 | FPR2 (0.48) | CTSSLMNAMAPT | |
| SCHEMBL7316845 | 0.70 | CTSS (0.41) | CTSKCTSLCTSSREN | |
| SCHEMBL9641169 | 0.70 | CTSS (0.41) | CTSKCTSLCTSSREN | |
| SCHEMBL9271695 | 0.70 | HMOX1 (0.41) | LMNAMAPTTDP1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |