Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 8/20 | 0.75 |
| ▸ | NOS1 | P29475 | 8/20 | 0.75 |
| ▸ | NOS2 | P35228 | 8/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5834017 | 0.86 | NOS3 (1.00) | NOS3NOS1NOS2TDP1HRH3 | |
| SCHEMBL5833909 | 0.85 | NOS3 (0.98) | NOS3NOS1NOS2TDP1HRH3 | |
| SCHEMBL7083997 | 0.79 | NOS3 (0.85) | NOS3NOS1NOS2TDP1HRH3 | |
| SCHEMBL5834368 | 0.77 | NOS3 (1.00) | NOS3NOS1NOS2 | |
| SCHEMBL7126075 | 0.76 | NOS3 (0.79) | NOS3NOS1NOS2HRH3HTR2A | |
| SCHEMBL5833641 | 0.76 | NOS3 (0.81) | NOS3NOS1NOS2 | |
| SCHEMBL7126072 | 0.76 | NOS3 (0.60) | NOS3NOS1NOS2HRH3HTR2A | |
| SCHEMBL5833437 | 0.74 | NOS1 (0.78) | NOS3NOS1NOS2HTR2AHTR7 | |
| SCHEMBL14970486 | 0.74 | HRH3 (0.81) | NOS3NOS1NOS2TDP1HRH3 | |
| SCHEMBL5833259 | 0.73 | NOS3 (0.75) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007520-A1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NOS INHIBITORS | Pfizer Products Inc. (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010339-A1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NOS INHIBITORS | PFIZER PRODUCTS INC. (US) | 1999-03-04 | — | — | WO | disclosed |