Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.71 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.71 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.63 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.63 |
| ▸ | AKT1 | P31749 | 1/20 | 0.60 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.59 |
| ▸ | CHRNG | P07510 | 1/20 | 0.59 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.59 |
| ▸ | CHRND | Q07001 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12557242 | 0.90 | CHRNB2 (0.68) | CHRNB2CHRNA4 | |
| SCHEMBL4111623 | 0.90 | CHRNB2 (0.68) | CHRNB2CHRNA4 | |
| SCHEMBL7411369 | 0.90 | CHRNB2 (0.68) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7414636 | 0.88 | CHRNB2 (0.67) | CHRNB2CHRNA4 | |
| SCHEMBL9241903 | 0.83 | LTA4H (0.60) | CHRNB4CHRNA3 | |
| SCHEMBL9241900 | 0.83 | LTA4H (0.60) | CHRNB4CHRNA3 | |
| SCHEMBL905203 | 0.83 | CHRNA3 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| SCHEMBL3223507 | 0.83 | CHRNA3 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| SCHEMBL14068193 | 0.83 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| SCHEMBL905206 | 0.83 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |