SCHEMBL7409253

SCHEMBL7409253

CCOc1ccc(CC(C)=C=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.50
ACACB O00763 5/20 0.47
MEN1 O00255 1/20 0.46
LMNA P02545 1/20 0.46
CYP1A2 P05177 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
HPGD P15428 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 3/20 0.44
PARP10 Q53GL7 1/20 0.44
MAPT P10636 1/20 0.44
KDM4E B2RXH2 1/20 0.44
NLRP3 Q96P20 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7417003 0.81 HTT (0.55) MEN1KMT2ASMN1; SMN2ALDH1A1MAPT
SCHEMBL27661058 0.81 NQO1 (0.48) NQO1ACACBTDP1SMN1; SMN2NPC1
SCHEMBL2628188 0.79 POLB (0.59) NQO1MEN1LMNACYP1A2KMT2A
SCHEMBL6650453 0.79 NQO1 (0.61) NQO1MEN1LMNACYP1A2KMT2A
SCHEMBL503308 0.76 PLA2G4B (0.58) NQO1TDP1SMN1; SMN2NPC1HPGD
SCHEMBL700166 0.74 PARP10 (0.61) NQO1LMNACYP1A2TDP1ALDH1A1
SCHEMBL10884546 0.74 NQO1 (0.54) NQO1MEN1LMNACYP1A2KMT2A
SCHEMBL2126901 0.74 NQO1 (0.54) NQO1MEN1LMNACYP1A2KMT2A
SCHEMBL2528806 0.74 ALDH1A1 (0.54) NQO1MEN1LMNACYP1A2KMT2A
SCHEMBL6709316 0.74 NQO1 (0.54) NQO1MEN1LMNACYP1A2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6482824-B1 Use of n-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives as selective mglur1 antagonists ELI LILLY AND COMPANY 2002-11-19 US disclosed
EP-1124806-A2 USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS ELI LILLY AND COMPANY LIMITED (GB) 2001-08-22 EP disclosed
WO-2000026199-A2 USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS ELI LILLY AND COMPANY LIMITED (GB) 2000-05-11 WO disclosed
WO-2000026198-A1 N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MGLUR1 ANTAGONISTS ELI LILLY AND COMPANY LIMITED (GB) 2000-05-11 WO disclosed