Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409253 | 0.81 | NQO1 (0.50) | SMN1; SMN2KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL28709451 | 0.78 | HTT (0.66) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL48525 | 0.78 | HTT (0.66) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL3665017 | 0.77 | HTT (0.59) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL7370074 | 0.75 | HTT (0.57) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL6802365 | 0.75 | CES1 (0.50) | CTBP2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3628705 | 0.75 | HTT (0.68) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL1525068 | 0.74 | HTT (0.66) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL240822 | 0.74 | KDM4E (0.74) | HTTSMN1; SMN2PKMCTBP2KDM4E | |
| SCHEMBL7149097 | 0.73 | HTT (0.59) | HTTSMN1; SMN2PKMCTBP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482824-B1 | Use of n-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives as selective mglur1 antagonists | ELI LILLY AND COMPANY | 2002-11-19 | — | — | US | disclosed |
| EP-1124806-A2 | USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026198-A1 | N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MGLUR1 ANTAGONISTS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000026199-A2 | USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-05-11 | — | — | WO | disclosed |