Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570533 | 0.79 | HAO1 (0.50) | KDM4EYTHDC1STAT3HIF1ACCNA2 | |
| SCHEMBL7304420 | 0.79 | PRKAG1 (0.36) | KDM4EYTHDC1STAT3HIF1APRKAG1 | |
| Hydrochloric Acid SCHEMBL9444673 | 0.78 | HAO1 (0.49) | KDM4EYTHDC1STAT3HIF1ACCNA2 | |
| SCHEMBL28497966 | 0.77 | PARP1 (0.45) | KDM4EYTHDC1STAT3HIF1APRKAG1 | |
| SCHEMBL1967918 | 0.77 | GPR17 (0.43) | KDM4EYTHDC1STAT3HIF1APRKAG1 | |
| SCHEMBL28503102 | 0.76 | PARP1 (0.44) | KDM4EYTHDC1STAT3HIF1APRKAG1 | |
| SCHEMBL16240884 | 0.76 | CTNNB1 (0.44) | KDM4EYTHDC1STAT3HIF1APRKAG1 | |
| SCHEMBL7374273 | 0.76 | GAA (0.54) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7420704 | 0.75 | KDM4E (0.39) | KDM4EYTHDC1STAT3HIF1APRKAG1 | |
| SCHEMBL492585 | 0.75 | CTNNB1 (0.48) | KDM4ESTAT3HIF1APRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |