Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407133 | 0.71 | NTSR1 (0.42) | PRKCINTSR1 | |
| SCHEMBL218056 | 0.71 | PRKCI (0.58) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL31265088 | 0.71 | PRKCI (0.58) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL17076858 | 0.70 | MAOA (0.49) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL6789563 | 0.69 | PRKCI (0.56) | PRKCINTSR1PLAUHTR6HTR2C | |
| Hydrochloric Acid SCHEMBL7361184 | 0.69 | PRKCI (0.56) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL16370787 | 0.68 | PRKCI (0.55) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL30672832 | 0.68 | PRKCI (0.55) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL13836419 | 0.68 | PRKCI (0.55) | PRKCINTSR1PLAUHTR6HTR2C | |
| SCHEMBL3650822 | 0.68 | PRKCI (0.59) | PRKCINTSR1PLAUHTR6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |