Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409091 | 0.81 | MEN1 (0.46) | MAPTMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL7409272 | 0.76 | MEN1 (0.46) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL8185391 | 0.72 | RAB9A (0.43) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL7407393 | 0.68 | GRIN2B (0.42) | PKMGRIN2BP2RX4 | |
| SCHEMBL7511371 | 0.66 | NPC1 (0.43) | RAB9ANPC1L3MBTL1 | |
| SCHEMBL10489919 | 0.65 | KDM4E (0.44) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL12542456 | 0.64 | RXFP1 (0.68) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL10117986 | 0.63 | P2RX3 (0.55) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL6624123 | 0.63 | F2 (0.46) | RAB9AMAPK1GAANPC1NPSR1 | |
| SCHEMBL11885515 | 0.62 | MAP3K5 (0.57) | MAPTMEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015454-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-2000018770-A1 | PYRROLOPYRROLONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXO GROUP LIMITED (GB) | 2000-04-06 | — | — | WO | disclosed |
| EP-0973775-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999012932-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |
| WO-1998043975-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |