Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 4/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405571 | 0.84 | TOP2A (0.49) | ENPP2SYKMEN1ALDH1A1AR | |
| SCHEMBL27903338 | 0.78 | HTR6 (0.53) | HTR6BPTFLOXL2BRD4PNMT | |
| SCHEMBL27473567 | 0.77 | ALDH1A1 (0.60) | HTR6BPTFLOXL2BRD4PNMT | |
| SCHEMBL27982990 | 0.75 | SIRT1 (0.53) | HTR6BPTFLOXL2BRD4PNMT | |
| SCHEMBL693995 | 0.75 | RAPGEF4 (0.45) | MEN1ALDH1A1ARMAPTKMT2A | |
| SCHEMBL72023 | 0.74 | HSD17B10 (0.50) | MEN1ALDH1A1ARMAPTKMT2A | |
| SCHEMBL8725838 | 0.74 | EGFR (0.39) | MEN1ALDH1A1ARMAPTKMT2A | |
| Biphenyl SCHEMBL27570267 | 0.73 | TAAR1 (0.55) | HTR6LOXL2PNMTENPP2CFD | |
| SCHEMBL6986651 | 0.71 | MEN1 (0.53) | MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL693983 | 0.71 | IDH2 (0.54) | MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948525-A1 | CYCLIC PEPTIDE DERIVATIVES | MERCK PATENT GmbH (DE) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998027112-A1 | CYCLIC PEPTIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 1998-06-25 | — | — | WO | disclosed |