Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765031 | 0.91 | P2RX3 (0.45) | P2RX3P2RX2KDM4EALDH1A1GLA | |
| SCHEMBL26263181 | 0.84 | KDM4E (0.40) | POLBP2RX3P2RX2KDM4EALDH1A1 | |
| SCHEMBL740716 | 0.82 | CYP2D6 (0.41) | P2RX3P2RX2KCNH2HPGDSTRPV3 | |
| SCHEMBL740717 | 0.82 | CYP2D6 (0.41) | P2RX3P2RX2KCNH2HPGDSTRPV3 | |
| SCHEMBL762854 | 0.80 | P2RX7 (0.42) | POLBALDH1A1KCNH2HPGDSJAK2 | |
| SCHEMBL762590 | 0.80 | P2RX7 (0.42) | POLBALDH1A1HPGDCNR2KCNH2 | |
| SCHEMBL741975 | 0.79 | KCNH2 (0.52) | POLBKCNH2HPGDSCYP2D6HRH1 | |
| SCHEMBL741974 | 0.79 | KCNH2 (0.52) | POLBKCNH2HPGDSCYP2D6HRH1 | |
| SCHEMBL762531 | 0.79 | TLR8 (0.44) | CNR2TLR8HPGDSTP53 | |
| SCHEMBL740966 | 0.79 | KCNH2 (0.44) | POLBP2RX3P2RX2CNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |