Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.74 |
| ▸ | MMP1 | P03956 | 12/20 | 0.74 |
| ▸ | MMP13 | P45452 | 11/20 | 0.74 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.74 |
| ▸ | MMP2 | P08253 | 6/20 | 0.52 |
| ▸ | MMP3 | P08254 | 6/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927179 | 0.86 | MMP1 (1.00) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL1847769 | 0.86 | MMP1 (1.00) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6927165 | 0.84 | ALOX5 (0.53) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6929348 | 0.84 | ALOX5 (0.53) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6934185 | 0.83 | ALOX5 (0.53) | MMP9MMP1MMP13ADAM17ALOX5 | |
| SCHEMBL6929323 | 0.82 | MMP13 (1.00) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6930079 | 0.81 | MMP9 (0.70) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6933449 | 0.81 | MMP13 (0.72) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6933028 | 0.81 | MMP13 (0.72) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6928553 | 0.81 | MMP13 (0.72) | MMP9MMP1MMP13ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054858-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042436-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-08-26 | — | — | WO | disclosed |