Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 4/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410235 | 0.86 | LMNA (0.44) | APLNRALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL7411523 | 0.81 | OXER1 (0.44) | PPARAALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL7218658 | 0.80 | NR4A2 (0.59) | GAAGLAALDH1A1HPGDKDM4E | |
| SCHEMBL7410219 | 0.78 | LMNA (0.49) | GAAALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL7416125 | 0.77 | NPC1 (0.39) | GAAAPLNRMAPTTSHRHTT | |
| SCHEMBL3263699 | 0.73 | GAA (0.48) | GAAGLAUTS2RALDH1A1HPGD | |
| SCHEMBL28025010 | 0.73 | GAA (0.53) | GAAGLAALDH1A1HPGDKDM4E | |
| SCHEMBL7409293 | 0.72 | PARP1 (0.45) | MEN1KMT2AL3MBTL1MAPTTUBB4A | |
| SCHEMBL7407743 | 0.72 | NR4A2 (0.44) | APLNRALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL7414744 | 0.72 | PBRM1 (0.44) | APLNRPPARAKDM4EMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |