Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621598 | 0.92 | LMNA (0.47) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7410235 | 0.92 | LMNA (0.44) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7411523 | 0.90 | OXER1 (0.44) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7412570 | 0.89 | LMNA (0.48) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7469182 | 0.89 | LMNA (0.47) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7474876 | 0.79 | NR4A2 (0.61) | LMNAL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL7407743 | 0.78 | NR4A2 (0.44) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7410285 | 0.78 | GAA (0.50) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL6686573 | 0.74 | AHR (0.51) | LMNAL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL7414744 | 0.72 | PBRM1 (0.44) | KDM4EMAPTHTTPIM1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |