SCHEMBL7410695

SCHEMBL7410695

C[C@H]1C(=O)N(c2nc3ccccc3s2)[C@@H]2CCN(C(=O)[C@@H]3CCCN3C(=O)OC(C)(C)C)[C@H]21

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7406898 1.00 L3MBTL1 (0.45) L3MBTL1
SCHEMBL7407549 0.96 GPR119 (0.44) L3MBTL1
SCHEMBL7408082 0.89
SCHEMBL7411267 0.89 L3MBTL1 (0.48) L3MBTL1
SCHEMBL7410495 0.88 L3MBTL1 (0.44) L3MBTL1
SCHEMBL7411222 0.88
SCHEMBL7408913 0.87
SCHEMBL7402247 0.87 L3MBTL1 (0.46) L3MBTL1
SCHEMBL7413206 0.87 UCHL1 (0.40)
SCHEMBL7412072 0.84 L3MBTL1 (0.41) L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015454-A1 METHOD OF INHIBITING SERINE PROTEASE ENZYMES GLAXO GROUP LIMITED (GB) 2000-07-05 EP disclosed
EP-0973775-A1 PYROLOPYRROLONE DERIVATIVES GLAXO GROUP LIMITED (GB) 2000-01-26 EP disclosed
WO-1999012932-A1 METHOD OF INHIBITING SERINE PROTEASE ENZYMES GLAXO GROUP LIMITED (GB) 1999-03-18 WO disclosed
WO-1998043975-A1 PYROLOPYRROLONE DERIVATIVES GLAXO GROUP LIMITED (GB) 1998-10-08 WO disclosed