Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409701 | 0.93 | PARP1 (0.61) | PARP1PARP2DRD2DRD3 | |
| SCHEMBL7410146 | 0.87 | PARP1 (0.61) | PARP1PARP2DRD2 | |
| SCHEMBL7409815 | 0.81 | PARP1 (0.60) | PARP1PARP2 | |
| SCHEMBL7409390 | 0.81 | PARP1 (0.58) | PARP1PARP2DRD2DRD1DRD4 | |
| SCHEMBL5621048 | 0.77 | PARP1 (0.88) | PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL18614331 | 0.76 | PARP1 (0.86) | PARP1PARP2 | |
| SCHEMBL738976 | 0.75 | POLB (0.63) | PARP1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6864930 | 0.74 | PARP1 (0.65) | PARP1PARP2 | |
| SCHEMBL7410253 | 0.74 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL7415524 | 0.73 | TSHR (0.39) | PARP1PARP2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |