Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113585 | 0.80 | POLB (0.40) | POLBARSMN1; SMN2KMT2AMDM2 | |
| SCHEMBL8113354 | 0.78 | ALDH1A1 (0.39) | POLBARSMN1; SMN2KMT2AMDM2 | |
| SCHEMBL8120212 | 0.78 | POLB (0.38) | POLBARSMN1; SMN2KMT2AMAPT | |
| SCHEMBL7412423 | 0.77 | POLB (0.38) | POLBARSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8121024 | 0.76 | TUBB4A (0.39) | POLBARSMN1; SMN2KMT2AMDM2 | |
| SCHEMBL8120011 | 0.74 | KMT2A (0.39) | POLBARSMN1; SMN2KMT2AMDM2 | |
| SCHEMBL7010702 | 0.69 | GRIN2D (0.48) | POLBSMN1; SMN2KMT2AGRIN2DGRIN3B | |
| SCHEMBL9268773 | 0.66 | POLB (0.71) | POLBARSMN1; SMN2MAPTGAA | |
| SCHEMBL13424741 | 0.66 | GRIN2D (0.43) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30433473 | 0.65 | POLB (0.66) | POLBARSMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082324-A4 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1082324-A1 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-0971891-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2000-04-19 | — | — | EP | disclosed |
| EP-0971891-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999061442-A1 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1998031670-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-07-23 | — | — | WO | disclosed |