Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120212 | 0.87 | POLB (0.38) | POLBKMT2AMEN1ARSMN1; SMN2 | |
| SCHEMBL7412766 | 0.83 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL8120011 | 0.81 | KMT2A (0.39) | POLBKMT2AMEN1ARSMN1; SMN2 | |
| SCHEMBL8121024 | 0.79 | TUBB4A (0.39) | POLBKMT2AMEN1ARSMN1; SMN2 | |
| SCHEMBL7410792 | 0.77 | POLB (0.44) | POLBKMT2AMEN1ARSMN1; SMN2 | |
| SCHEMBL8113585 | 0.72 | POLB (0.40) | POLBKMT2AMEN1ARSMN1; SMN2 | |
| SCHEMBL8113354 | 0.69 | ALDH1A1 (0.39) | POLBKMT2AMEN1ARSMN1; SMN2 | |
| SCHEMBL7362798 | 0.61 | POLB (0.39) | POLBKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9268773 | 0.60 | POLB (0.71) | POLBARSMN1; SMN2ALDH1A1 | |
| SCHEMBL30433473 | 0.59 | POLB (0.66) | POLBKMT2AARSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082324-A4 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1082324-A1 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-0971891-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2000-04-19 | — | — | EP | disclosed |
| EP-0971891-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999061442-A1 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1998031670-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-07-23 | — | — | WO | disclosed |