Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226378 | 0.85 | CA2 (0.63) | GAACDK1CA2CA1CA5A | |
| SCHEMBL30827404 | 0.85 | CA2 (0.63) | GAACDK1CA2CA1CA5A | |
| SCHEMBL7781881 | 0.85 | GAA (0.56) | GAACDK1CA2CA1CA5A | |
| SCHEMBL20529369 | 0.82 | CDK1 (0.48) | GAACDK1CA2CA1CA5A | |
| SCHEMBL9324149 | 0.82 | KDM4E (0.53) | GAACDK1CA2CA1CA5A | |
| SCHEMBL17078006 | 0.82 | TRPV4 (0.56) | CDK1CA2CA1CA5ACA9 | |
| SCHEMBL4349616 | 0.81 | L3MBTL1 (0.42) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL9714080 | 0.81 | GAA (0.51) | GAACDK1CA2CA1CA5A | |
| SCHEMBL22827956 | 0.81 | CDK1 (0.47) | CDK1CA2CA1CA5ACA9 | |
| SCHEMBL1816360 | 0.81 | KDM4E (0.54) | GAACDK1CA2CA1CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1136472-A1 | ARYL- AND HETEROARYLAMIDES OF CARBOALKOXYSULFANILIC ACIDS | Ashkinazi, Rimma Iliinichna (RU) | 2001-09-26 | — | — | EP | disclosed |
| EP-1124806-A2 | USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026198-A1 | N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MGLUR1 ANTAGONISTS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000026199-A2 | USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-05-11 | — | — | WO | disclosed |