Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233487 | 0.90 | EGFR (0.48) | RAB9AKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7241464 | 0.77 | CYP11B1 (0.42) | RAB9AKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7230585 | 0.76 | GRIN1 (0.45) | RAB9AKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7411403 | 0.74 | MLKL (0.45) | RAB9AKDM4ESMN1; SMN2KMT2ANPC1 | |
| SCHEMBL1691295 | 0.72 | SMN1; SMN2 (0.51) | RAB9AKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7231035 | 0.71 | CYP11B1 (0.40) | RAB9AKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7232083 | 0.71 | ALDH1A1 (0.42) | RAB9AKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8957996 | 0.71 | NPC1 (0.76) | RAB9ASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL18136531 | 0.70 | SMN1; SMN2 (0.64) | RAB9AKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1691156 | 0.69 | SMN1; SMN2 (0.60) | RAB9AKDM4ESMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002002557-A2 | 2-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES: A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-10 | — | — | WO | disclosed |