Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233487 | 0.85 | EGFR (0.48) | POLBKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7241464 | 0.80 | CYP11B1 (0.42) | KMT2APOLBCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7411401 | 0.76 | RAB9A (0.47) | KMT2APOLBKDM4EALDH1A1RAB9A | |
| SCHEMBL7232083 | 0.74 | ALDH1A1 (0.42) | KMT2APOLBKDM4EALDH1A1RAB9A | |
| SCHEMBL7231035 | 0.74 | CYP11B1 (0.40) | KMT2APOLBKDM4EALDH1A1RAB9A | |
| SCHEMBL7240406 | 0.73 | ALOX5 (0.43) | KMT2APOLBKDM4EALDH1A1RAB9A | |
| SCHEMBL7230558 | 0.72 | PSMD14 (0.37) | POLBCYP3A4KDM4EALDH1A1RAB9A | |
| SCHEMBL7230400 | 0.70 | SMN1; SMN2 (0.45) | CYP3A4KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1691295 | 0.70 | SMN1; SMN2 (0.51) | POLBCYP3A4KDM4EALDH1A1RAB9A | |
| SCHEMBL7243478 | 0.68 | CYP11B1 (0.40) | KMT2APOLBCYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552037-B2 | An imidazo(1,2-a)Pyridine compound useful for altering the signal-transducing activity of gamma-aminobuytric acid receptor | NEUROGEN CORPORATION | 2003-04-22 | — | — | US | claimed |
| US-20020032200-A1 | 2-Substituted imidazo[1,2-A]pyridine derivatives | NEUROGEN CORPORATION | 2002-03-14 | — | — | US | claimed |
| WO-2002002557-A2 | 2-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES: A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-10 | — | — | WO | claimed |
| US-6552037-B2 | An imidazo(1,2-a)Pyridine compound useful for altering the signal-transducing activity of gamma-aminobuytric acid receptor | NEUROGEN CORPORATION | 2003-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032200-A1 | 2-Substituted imidazo[1,2-A]pyridine derivatives | GABBR2, GABRP, GABBR1 | GRIN1 141/4885GRIN2B 41/4885CSNK1A1 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.