Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411663 | 1.00 | PTGS2 (0.47) | PTGS2BACE1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL7414440 | 0.90 | BACE1 (0.44) | PTGS2BACE1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL7414442 | 0.90 | BACE1 (0.44) | PTGS2BACE1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL16011445 | 0.80 | CYP1A2 (0.45) | ALDH1A1MAPTCYP1A2KMT2AMEN1 | |
| SCHEMBL192101 | 0.80 | HCAR3 (0.58) | PTGS2ALDH1A1MAPTHCAR3LMNA | |
| SCHEMBL3091095 | 0.80 | HCAR3 (0.58) | PTGS2ALDH1A1MAPTHCAR3LMNA | |
| SCHEMBL544067 | 0.76 | ALDH1A1 (0.48) | PTGS2BACE1ALDH1A1MAPTKMT2A | |
| SCHEMBL544066 | 0.76 | ALDH1A1 (0.48) | PTGS2BACE1ALDH1A1MAPTKMT2A | |
| SCHEMBL11264895 | 0.76 | TSHR (0.53) | PTGS2BACE1ALDH1A1MAPTKMT2A | |
| SCHEMBL11264900 | 0.76 | TSHR (0.53) | PTGS2BACE1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |