Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414442 | 1.00 | BACE1 (0.44) | BACE1ALDH1A1MAPTCYP1A2SIRT5 | |
| SCHEMBL7411663 | 0.90 | PTGS2 (0.47) | BACE1ALDH1A1MAPTCYP1A2STAT3 | |
| SCHEMBL7411665 | 0.90 | PTGS2 (0.47) | BACE1ALDH1A1MAPTCYP1A2STAT3 | |
| SCHEMBL7006042 | 0.80 | CASP6 (0.55) | BACE1ALDH1A1MAPT | |
| SCHEMBL7006045 | 0.80 | CASP6 (0.55) | BACE1ALDH1A1MAPT | |
| SCHEMBL7006049 | 0.80 | CASP6 (0.55) | BACE1ALDH1A1MAPT | |
| SCHEMBL11837128 | 0.77 | ATM (0.50) | BACE1ALDH1A1MAPTCYP1A2SIRT5 | |
| SCHEMBL11837114 | 0.77 | ATM (0.50) | BACE1ALDH1A1MAPTCYP1A2SIRT5 | |
| SCHEMBL13778767 | 0.77 | MAPT (0.48) | BACE1ALDH1A1MAPTPTGS2AKR1C3 | |
| SCHEMBL12367389 | 0.76 | TSHR (0.53) | BACE1ALDH1A1MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |