Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 12/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413545 | 0.92 | HTR1A (0.47) | HTR1FHTR6HTR1AHTR7SLC6A4 | |
| Hydrochloric Acid SCHEMBL7408528 | 0.91 | HTR1A (0.46) | HTR1FHTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL7402627 | 0.79 | CHRM3 (0.56) | HTR1FHTR1AHTR7CHRM3 | |
| SCHEMBL7414594 | 0.78 | HTR1F (0.48) | HTR1FHTR1AHTR7CFTR | |
| Hydrochloric Acid SCHEMBL7408008 | 0.78 | CHRM3 (0.55) | HTR1FHTR1AHTR7CHRM3 | |
| SCHEMBL7408892 | 0.78 | CHRM3 (0.43) | HTR1FHTR1AHTR7CHRM3 | |
| SCHEMBL7409117 | 0.78 | GFER (0.59) | HTR1FHTR6CHRM3 | |
| SCHEMBL7407854 | 0.77 | CHRM3 (0.44) | HTR1FHTR1AHTR7CHRM3 | |
| SCHEMBL7410521 | 0.77 | HTR1F (0.41) | HTR1FHTR6HTR1AHTR7CHRM3 | |
| SCHEMBL7413012 | 0.77 | TAAR1 (0.50) | HTR1FHTR6HTR1AHTR7SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4257952-A | PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES | STERLING DRUG INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4172834-A | ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS | STERLING DRUG INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4062864-A | ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3959309-A | ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1976-05-25 | — | — | US | disclosed |