Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | MMP9 | P14780 | 4/20 | 0.45 |
| ▸ | MMP8 | P22894 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.35 |
| ▸ | CAPN9 | O14815 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358000 | 0.83 | BMP1 (0.34) | MMP2MMP9MMP8 | |
| SCHEMBL7356614 | 0.80 | MMP2 (0.49) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7513209 | 0.80 | MMP1 (0.44) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL9010568 | 0.78 | MMP1 (0.35) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7405014 | 0.78 | SMN1; SMN2 (0.45) | MMP2MMP9MMP1CAPN1MMP3 | |
| SCHEMBL8422654 | 0.77 | MMP1 (0.34) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL8424797 | 0.77 | MMP1 (0.32) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL8189731 | 0.77 | MMP1 (0.32) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL9010596 | 0.76 | — | — | |
| SCHEMBL8198199 | 0.76 | ADAM17 (0.34) | MMP2MMP9MMP8MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919940-A | TERT-LEUCINE-THIAZOL-2-YLAMIDE | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| US-5859253-A | L-TERT-LEUCINE-2-PYRIDYLAMIDE | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| EP-0740652-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1998-05-06 | — | — | EP | disclosed |
| US-5747514-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-05-05 | — | — | US | disclosed |
| EP-0740652-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019956-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |