Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414387 | 0.90 | AKR1B1 (0.41) | AKR1B1AKR1B10AKR1A1MEN1ALDH1A1 | |
| SCHEMBL7414202 | 0.73 | MEN1 (0.37) | MEN1KMT2APTGDR2WDR5SRC | |
| SCHEMBL9043612 | 0.69 | POLB (0.46) | ALDH1A1KMT2AHTT | |
| SCHEMBL10341454 | 0.66 | KMT2A (0.49) | MEN1ALDH1A1KMT2A | |
| SCHEMBL2820833 | 0.66 | AKR1B1 (0.90) | AKR1B1AKR1B10AKR1A1PTGDR2 | |
| SCHEMBL2822156 | 0.66 | AKR1B1 (0.70) | AKR1B1AKR1B10AKR1A1ALDH1A1HTT | |
| SCHEMBL15083046 | 0.62 | BRD4 (0.51) | — | |
| SCHEMBL11492920 | 0.62 | FKBP1A (0.48) | MEN1ALDH1A1KMT2A | |
| SCHEMBL9913677 | 0.60 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1PTGDR2 | |
| SCHEMBL10778316 | 0.60 | MAPT (0.59) | MEN1ALDH1A1GAAKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |