Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412002 | 0.90 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1KMT2AMEN1 | |
| SCHEMBL7414202 | 0.83 | MEN1 (0.37) | KMT2AMEN1PTGDR2 | |
| SCHEMBL7411910 | 0.70 | CYP2C19 (0.37) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL14033586 | 0.64 | HTT (0.35) | KMT2AALDH1A1 | |
| SCHEMBL4752558 | 0.64 | KCNH2 (0.36) | AKR1B1KMT2AMEN1RAB9A | |
| SCHEMBL7411167 | 0.64 | PTGDR2 (0.46) | KMT2AMEN1ALDH1A1PTGDR2 | |
| SCHEMBL2820833 | 0.63 | AKR1B1 (0.90) | AKR1B1AKR1B10AKR1A1PTGDR2 | |
| SCHEMBL9437361 | 0.62 | L3MBTL1 (0.64) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL9043612 | 0.62 | POLB (0.46) | KMT2AALDH1A1 | |
| SCHEMBL11492920 | 0.59 | FKBP1A (0.48) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |
| WO-1992000741-A1 | 2-AMINO-1,4-DIHYDROPYRIDINE DERIVATIVES WITH CALCIUM AGONIST AND ALPHA1-ANTAGONIST ACTIVITY | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-23 | — | — | WO | disclosed |