Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 3/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411910 | 0.87 | CYP2C19 (0.37) | MEN1KMT2ASRCWDR5ATM | |
| SCHEMBL7414387 | 0.83 | AKR1B1 (0.41) | MEN1KMT2APTGDR2 | |
| SCHEMBL7412002 | 0.73 | AKR1B1 (0.43) | MEN1KMT2ASRCPTGDR2WDR5 | |
| SCHEMBL7415419 | 0.65 | KDM4E (0.41) | — | |
| SCHEMBL7413021 | 0.62 | KDM4E (0.45) | MEN1KMT2ASRC | |
| SCHEMBL1120381 | 0.60 | AKR1B1 (0.66) | PER2CRY2PTGDR2 | |
| SCHEMBL12848451 | 0.60 | FPR2 (0.44) | MEN1KMT2A | |
| SCHEMBL9734334 | 0.59 | NPC1 (0.42) | MEN1KMT2A | |
| SCHEMBL31530864 | 0.58 | NOTUM (0.45) | MEN1KMT2A | |
| SCHEMBL7408771 | 0.58 | KDM4E (0.52) | MEN1KMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |