Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.31 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412499 | 0.80 | MAPT (0.37) | MAPTHPGDSMN1; SMN2CASP3POLB | |
| SCHEMBL7414611 | 0.79 | PDE3B (0.49) | SMYD3 | |
| SCHEMBL23535779 | 0.79 | CASP3 (0.54) | MAPTHPGDSMN1; SMN2CASP3POLB | |
| SCHEMBL30040559 | 0.79 | CASP3 (0.54) | MAPTHPGDSMN1; SMN2CASP3POLB | |
| SCHEMBL9729853 | 0.77 | SMN1; SMN2 (0.53) | MAPTSMN1; SMN2POLBALDH1A1HTT | |
| SCHEMBL7343775 | 0.75 | CYP11B2 (0.40) | POLBALDH1A1HSD17B10 | |
| SCHEMBL23535782 | 0.74 | LMNA (0.49) | MAPTHPGDPOLBALDH1A1SMYD3 | |
| SCHEMBL30040376 | 0.74 | LMNA (0.49) | MAPTHPGDPOLBALDH1A1SMYD3 | |
| SCHEMBL7342699 | 0.73 | USP30 (0.46) | MAPTSMN1; SMN2POLBALDH1A1KDM4E | |
| SCHEMBL9589587 | 0.72 | SLC9A1 (0.43) | MAPTHPGDSMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906630-A | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds | RORER PHARMACEUTICAL CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| US-4868300-A | INOTROPIC AGENTS, CONGESTIVE HEART FAILURE | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-19 | — | — | US | disclosed |
| US-4785101-A | CONGESTIVE HEART FAILURE | RORER PHARMACEUTICAL CORPORATION (US) | 1988-11-15 | — | — | US | disclosed |
| EP-0247177-A4 | BENZODIAZINONE-PYRIDAZINONE AND HYDROXY-PYRAZOLYL COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES. | RORER INTERNAT OVERSEAS INC (US) | 1988-04-06 | — | — | EP | disclosed |
| US-4725686-A | CONGESTIVE HEART FAILURE | WILLIAM H. RORER, INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0247177-A1 | BENZODIAZINONE-PYRIDAZINONE AND HYDROXY-PYRAZOLYL COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-12-02 | — | — | EP | disclosed |
| WO-1987003201-A1 | BENZODIAZINONE-PYRIDAZINONE AND HYDROXY-PYRAZOLYL COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-06-04 | — | — | WO | disclosed |