Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14786664 | 0.81 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL21258291 | 0.80 | MEN1 (0.55) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL11015731 | 0.80 | MEN1 (0.55) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL25205668 | 0.79 | L3MBTL1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL26415297 | 0.79 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL11863185 | 0.78 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL7423707 | 0.78 | TRPM8 (0.47) | ALDH1A1SMN1; SMN2POLBLMNAHSD17B10 | |
| SCHEMBL4927817 | 0.78 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL22769372 | 0.77 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA | |
| SCHEMBL8316510 | 0.77 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1SMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265903-A1 | THIEPINO[3,2-B]DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6420383-B1 | CALCIUM CHANNEL BLOCKERS, HYPERSENSITIVITY, ALLERGY, ASTHMA, BRONCHOSPASM, DYSMENORRHEA, ESOPHAGEAL SPASM, GLAUCOMA, PREMATURE LABOR, URINARY TRACT DISORDERS, GASTROINTESTINAL MOTILITY DISORDERS AND CARDIOVASCULAR DISORDERS. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-07-16 | — | — | US | disclosed |
| WO-2001070748-A1 | THIEPINO [3,2-b] DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |