Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 15/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426272 | 0.81 | TRPM8 (0.48) | TRPM8SMN1; SMN2HSD17B10RIPK1POLB | |
| SCHEMBL7412667 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2HSD17B10POLBALDH1A1LMNA | |
| SCHEMBL11160693 | 0.77 | CTSC (0.48) | TRPM8SMN1; SMN2HSD17B10TDP1ALDH1A1 | |
| Ethyl Acetate SCHEMBL27942747 | 0.73 | TRPM8 (0.51) | TRPM8SMN1; SMN2HSD17B10RIPK1POLB | |
| SCHEMBL9009605 | 0.72 | MEN1 (0.54) | SMN1; SMN2HSD17B10TDP1ALDH1A1LMNA | |
| SCHEMBL8332586 | 0.72 | SMN1; SMN2 (0.48) | TRPM8SMN1; SMN2HSD17B10POLBTDP1 | |
| SCHEMBL7450943 | 0.71 | CYP2C19 (0.64) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL12539260 | 0.71 | TRPM8 (0.62) | TRPM8 | |
| SCHEMBL4103378 | 0.70 | CYP2C19 (0.53) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL12539047 | 0.70 | HSD11B1 (0.52) | TRPM8SMN1; SMN2HSD17B10RIPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265903-A1 | THIEPINO[3,2-B]DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6420383-B1 | CALCIUM CHANNEL BLOCKERS, HYPERSENSITIVITY, ALLERGY, ASTHMA, BRONCHOSPASM, DYSMENORRHEA, ESOPHAGEAL SPASM, GLAUCOMA, PREMATURE LABOR, URINARY TRACT DISORDERS, GASTROINTESTINAL MOTILITY DISORDERS AND CARDIOVASCULAR DISORDERS. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-07-16 | — | — | US | disclosed |
| WO-2001070748-A1 | THIEPINO [3,2-b] DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |