Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072632 | 0.83 | ALDH1A1 (0.42) | MAOAMAOBKDM4EGPR3SMN1; SMN2 | |
| SCHEMBL8585832 | 0.71 | GRM2 (0.47) | KDM4EGPR3SMN1; SMN2PDPK1CA12 | |
| SCHEMBL28417673 | 0.71 | MEN1 (0.42) | MAOAMAOBKDM4EGPR3SMN1; SMN2 | |
| SCHEMBL8641190 | 0.69 | ALOX5 (0.53) | ALOX5MAOAMAOBKDM4EKCNJ1 | |
| SCHEMBL8874682 | 0.68 | KDM4E (0.42) | KDM4EGPR3SMN1; SMN2PDPK1CA12 | |
| SCHEMBL2199956 | 0.68 | MAOA (0.34) | ALOX5MAOAMAOBKDM4EKCNJ1 | |
| SCHEMBL1191742 | 0.68 | MET (0.42) | KDM4EGPR3SMN1; SMN2PDPK1CA12 | |
| SCHEMBL16836537 | 0.68 | KDM4E (0.39) | MAOAMAOBKDM4EGPR3SMN1; SMN2 | |
| SCHEMBL7404594 | 0.67 | UGCG (0.49) | KDM4ENPC1RAB9A | |
| SCHEMBL23120251 | 0.67 | KDM4E (0.38) | KDM4EGPR3SMN1; SMN2PDPK1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604235-A | DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, BENZODIAZEPINE OVERDOSE; ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION (US) | 1997-02-18 | — | — | US | disclosed |
| WO-1994026741-A1 | CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |