SCHEMBL7412915

SCHEMBL7412915

O=C1CN=C(c2ccccc2)c2cc(Cl)sc2N1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 0.59
OPRK1 P41145 2/20 0.59
CNR1 P21554 1/20 0.59
NTSR1 P30989 1/20 0.59
GABRA1 P14867 4/20 0.56
GABRA5 P31644 4/20 0.56
GABRA3 P34903 4/20 0.56
GABRA2 P47869 4/20 0.56
GABRB2 P47870 4/20 0.56
GABRG2 P18507 3/20 0.56
GABRB3 P28472 3/20 0.56
PGR P06401 1/20 0.51
HTR1A P08908 1/20 0.51
ADRA2A P08913 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
AR P10275 1/20 0.51
PDE4A P27815 1/20 0.51
ADRA1A P35348 1/20 0.51
HPGD P15428 2/20 0.48
ALDH1A1 P00352 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7315953 0.85 GABRA1 (0.60) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL11507198 0.84 CHRM1 (0.59) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL11508834 0.83 LMNA (0.61) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL11508830 0.82 ADRA1A (0.56) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL11510293 0.81 LMNA (0.46) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL11512290 0.80 LMNA (0.44) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL11508404 0.79 GABRA1 (0.58) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL7314511 0.78 PDE4D (0.42) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL7310202 0.78 PDE4D (0.42) PDE4DOPRK1CNR1NTSR1GABRA1
SCHEMBL7089809 0.76 GABRA1 (0.60) PDE4DOPRK1CNR1NTSR1GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4425272-A ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1984-01-10 US disclosed
US-4401597-A INTERMEDIATES FOR ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVE AND ANXIOLYTICS HOFFMANN-LA ROCHE INC. (US) 1983-08-30 US disclosed
US-4390471-A INTERMEDIATES FOR IMIDOBENZODIAZEPINE AND ANALOGS HOFFMANN-LA ROCHE INC. (US) 1983-06-28 US disclosed
US-4376075-A REACTION OF AN AMINODERIVATIVE THEREOF WITH AN ALDEHYDE HOFFMANN-LA ROCHE INC. (US) 1983-03-08 US disclosed
US-4371468-A ANTICONVULSANTS, MUSCLE RELAXANTS, AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-02-01 US disclosed
US-4368157-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4368159-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4368158-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4349476-A IMIDAZO/1,5-A//1,4) BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINE HOFFMANN-LA ROCHE INC. (US) 1982-09-14 US disclosed
US-4349477-A IMIPAZO/1,5-A//1,4/BENZO-, THIENO- OR PYRAZOLODIAZEPINES FROM 2-DIMORPHOLINOPHOSPHONATES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINES HOFFMANN-LA ROCHE INC. (US) 1982-09-14 US disclosed
US-4349475-A IMIDAZO/1,5-A//1,4/BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZOTHIENO-OR PYRAZOLODIAZEPINES HOFFMANN-LA ROCHE INC. (US) 1982-09-14 US disclosed
US-4307237-A ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS HOFFMANN-LA ROCHE INC. (US) 1981-12-22 US disclosed
US-4280957-A Imidazodiazepines and processes therefor HOFFMANN-LA ROCHE INC. (US) 1981-07-28 US disclosed
US-4155913-A ANTICONBULSANTS, MUSCLE RELAXANTS AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1979-05-22 US disclosed