Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590297 | 1.00 | CYP3A4 (0.34) | CYP3A4ALDH1A1CYP2C9CYP2C19MME | |
| SCHEMBL6588900 | 0.90 | NAAA (0.35) | NAAA | |
| SCHEMBL7412446 | 0.90 | NAAA (0.35) | NAAA | |
| SCHEMBL6589398 | 0.89 | CTSL (0.38) | CYP3A4ALDH1A1CYP2C9CYP2C19NAAA | |
| SCHEMBL7420898 | 0.89 | CTSL (0.38) | CYP3A4ALDH1A1CYP2C9CYP2C19NAAA | |
| SCHEMBL7416310 | 0.84 | MAPT (0.33) | — | |
| SCHEMBL6586616 | 0.84 | MAPT (0.33) | — | |
| SCHEMBL6586151 | 0.84 | ALDH1A1 (0.31) | CYP3A4ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6590478 | 0.83 | HRH3 (0.34) | CYP3A4ALDH1A1CYP2C9CYP2C19MME | |
| SCHEMBL7418471 | 0.79 | CTSL (0.37) | NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002544274-A | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-1178986-A2 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | Medivir UK Ltd (GB) | 2002-02-13 | — | — | EP | claimed |
| WO-2000069855-A2 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | MEDIVIR UK LIMITED (GB) | 2000-11-23 | — | — | WO | claimed |
| EP-1178986-A2 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | Medivir UK Ltd (GB) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000069855-A2 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | MEDIVIR UK LIMITED (GB) | 2000-11-23 | — | — | WO | disclosed |