Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.47 |
| ▸ | ACE | P12821 | 8/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997234 | 0.79 | DPP4 (0.47) | DPP4ACEACE2DPP8DPP7 | |
| SCHEMBL31410861 | 0.79 | OPRM1 (0.60) | OPRM1 | |
| SCHEMBL20872347 | 0.79 | F2 (0.53) | DPP4ACEDPP8DPP7F2 | |
| Hydrochloric Acid SCHEMBL27869972 | 0.78 | F2 (0.52) | DPP4ACEDPP8DPP7F2 | |
| SCHEMBL29697068 | 0.78 | OPRM1 (0.52) | DPP4DPP8DPP7OPRM1 | |
| SCHEMBL7293351 | 0.76 | ACE (0.57) | DPP4ACEACE2F2 | |
| SCHEMBL7293358 | 0.76 | ACE (0.57) | DPP4ACEACE2F2 | |
| SCHEMBL25129445 | 0.76 | FKBP1A (0.55) | DPP4ACEDPP8DPP7FAP | |
| SCHEMBL7290929 | 0.76 | FKBP1A (0.55) | DPP4ACEDPP8DPP7FAP | |
| SCHEMBL30123062 | 0.75 | OPRM1 (0.48) | DPP4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261624-A1 | TRH-LIKE PEPTIDE DERIVATIVES AS INHIBITORS OF THE TRH-DEGRADING ECTOENZYME | The Provost, Fellows and Scholars of the College of the Holy and Undivide Trinity of Queen Elisabeth near Dublin (IE) | 2002-12-04 | — | — | EP | claimed |
| WO-2001060843-A1 | TRH-LIKE PEPTIDE DERIVATIVES AS INHIBITORS OF THE TRH-DEGRADING ECTOENZYME | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2001-08-23 | — | — | WO | claimed |