Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841370 | 0.87 | CREBBP (0.50) | KDM4ECREBBPALDH1A1LMNARAB9A | |
| SCHEMBL7413801 | 0.85 | LMNA (0.57) | CREBBPALDH1A1LMNARAB9AMAPT | |
| SCHEMBL30767099 | 0.80 | NOTUM (0.59) | KDM4EALDH1A1LMNANPSR1HPGD | |
| SCHEMBL5696394 | 0.80 | NOTUM (0.59) | KDM4EALDH1A1LMNANPSR1HPGD | |
| SCHEMBL9389498 | 0.80 | KCNH2 (0.52) | KDM4EALDH1A1LMNAHPGDRAB9A | |
| SCHEMBL8810927 | 0.77 | KDM4E (0.54) | KDM4ECREBBPALDH1A1LMNANPSR1 | |
| SCHEMBL5803388 | 0.76 | CA12 (0.50) | LMNARAB9AMAPTTP53MEN1 | |
| SCHEMBL8809305 | 0.76 | KDM4E (0.58) | KDM4EALDH1A1LMNANPSR1HPGD | |
| SCHEMBL4008891 | 0.75 | NOS3 (0.46) | KDM4EALDH1A1LMNANPSR1HPGD | |
| SCHEMBL6984459 | 0.74 | FPR1 (0.44) | CREBBPALDH1A1LMNAHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757687-A1 | TRICYCLIC DERIVATIVES AS 5HT 2C? AND 5HT 2B? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029177-A1 | TRICYCLIC DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-02 | — | — | WO | disclosed |