SCHEMBL7413854

SCHEMBL7413854

Fc1ncc(OCN2CCC2)cc1Cl

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.33
CXCR1 P25024 2/20 0.33
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
POLB P06746 1/20 0.33
SCN9A Q15858 2/20 0.32
HRH3 Q9Y5N1 2/20 0.32
CHRNB1 P11230 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNB3 Q05901 1/20 0.31
RPS6KB1 P23443 1/20 0.31
AKT1 P31749 1/20 0.31
MCHR1 Q99705 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7414269 0.83 CHRNB2 (0.45) KDM4ECXCR1ALDH1A1SMN1; SMN2POLB
SCHEMBL7479403 0.81 CXCR1 (0.35) CXCR1HRH3CHRNB2
SCHEMBL7463943 0.81 CHRNB2 (0.43) KDM4ECXCR1ALDH1A1SMN1; SMN2POLB
SCHEMBL27489539 0.75 ALDH1A1 (0.41) ALDH1A1CHRNB2
SCHEMBL7404714 0.74 GRM5 (0.38) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL7416361 0.74 ALDH1A1 (0.40) ALDH1A1CHRNB2
Hydrochloric Acid SCHEMBL7670697 0.73 CHRNB2 (0.46) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL7464431 0.73 CHRNB2 (0.37) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL3661229 0.72 CHRNB2 (0.43) CXCR1HRH3CHRNB2
SCHEMBL3662113 0.72 CHRNA3 (0.51) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP claimed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO claimed
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed